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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Frontiers of Medicine doi: 10.1007/s11684-023-1017-7

Abstract: The association of neurogenesis and gliogenesis with glioma remains unclear.By conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitiveoligodendrocyte precursor cell (pri-OPC)-like and radial glia (RG)-like tumors and validated it in apublic cohort and TCGA glioma.For example, glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

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Experimental study on BPA uptake of glioma cell lines

Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 85-90

Abstract:

Objective: to evaluate the incorporation of BPA by glioma cell lines,cells was increasing with the increasing concentration of BPA, and the boron concentration ratios of gliomaConclusion: BPA has a selectivity for glioma cells, and the results of the efflux assay confirm the temperature

Keywords： boron neutron capture therapy     BPA     glioma cell line     ICP AES    

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Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 119-129 doi: 10.1007/s11684-009-0022-9

Abstract: In order to provide a sensitive cell line model for investigating the mechanisms underlying the lymphaticline with high lymphatic metastatic potential (Hca-P/L ) was established and the effect of curcumininoculated into the medioventral line of a mouse 615 and the first generation of metastatic tumor cellsproliferation of Hca-P and Hca-P/L was observed by inverted microscope, cell growth curve and cellHca-P/L is a novel sensitive cell line model for investigating the mechanisms underlying tumor lymphatic

Keywords： murine ascites hepatocarcinoma cell line     metastasis     curcumin     drug sensitivity    

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Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cellline A549

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 359-363 doi: 10.1007/s11684-007-0069-4

Abstract: cycle control of the lung cancer cell line A549.Cell proliferation was assessed by cell counting kit-8 (CCK-8).Taken together, the inhibition of pirh2 expression in the lung adenocarcinoma cell line A549 resultedin reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis andthe interruption of cell cycle transition.

Keywords： control     interruption     cytoplasm     number     growth    

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract: However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cellsCurrent NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potentiallines and genetically modifying fresh NK cells or NK cell lines.The stable allogeneic NK cell line approach is more practical for quality-control and large-scale productionIn this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

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Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 766-772 doi: 10.1007/s11684-021-0916-8

Abstract: Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapiesThis study aimed to investigate the efficacy and safety of anlotinib as third- or further-line therapyFor patients with short-term relapsed SCLC, third- or further-line anlotinib treatment was associated

Keywords： anlotinib     chemotherapy     short-term relapsed     small-cell lung cancer    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cellline via ERKs pathway

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: investigate the extracellular regulated protein kinases (ERKs) pathway of HBx on glomerular mesangial cellPCI-neo containing HBV X gene (pCI-neo-X) was then transfected into cultured GMC line via liposome.HBx upregulates TNF-α expression and induces cell proliferation of GMC line partly through ERK signal

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stabilityElevated activities of cell proliferation, genomic instability and microenvironment, rather than subtypeMalignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitorcell compartment, respectively.

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7cHere, we confirmed that RGS16 is upregulated in glioma tissues and that high expression of RGS16 is associatedEctopic deletion of RGS16 significantly suppressed glioma cell proliferation and migration both inThus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and mayserve as a potential prognostic biomarker and therapeutic target in glioma.

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: Glioma is the most common lethal tumor of the human brain.The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 monthsThe underlying mechanism of glioma recurrence and evolution patterns of glioma are different from thoseHowever, the detailed reasons for the progression and recurrence of glioma remain controversial.In this review, we introduce the different mechanisms involved in glioma progression, including tumor

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 323-328 doi: 10.1007/s11684-010-0026-5

Abstract: nuclear factor-kappa B (NF-κB) inhibitor Bay 11-7082 on Fas/FasL system and Fas-mediated apoptosis in cellline HL-60 cells.

Keywords： nuclear factor-kappa B     Fas/FasL system     HL-60     Bay 11-7082    

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Acoustic fault signal extraction via the line-defect phononic crystals

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 1,   Pages 10-10 doi: 10.1007/s11465-021-0666-y

Abstract: In this paper, 2D line-defect phononic crystals (PCs) consisting of periodic acrylic tubes with slitThe defect band, namely, the formed resonance band of line-defect PCs enables the incident acoustic waveThe effectiveness of weak harmonic and periodic impulse signal detection via line-defect PCs are investigatedAll the numerical and experimental results indicate that line-defect PCs can be well used for extracting

Keywords： phononic crystals     line-defect     fault signal extraction     acoustic enhancement    

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Calculations of narrow-band transimissities and the Planck mean absorption coefficients of real gases using line-by-line

Huaqiang CHU, Mingyan GU, Huaichun ZHOU, Fengshan LIU

Frontiers in Energy 2014, Volume 8, Issue 1,   Pages 41-48 doi: 10.1007/s11708-013-0292-4

Abstract: the band parameters of Soufiani and Taine, the more recent parameters of André and Vaillon, and the line-by-line

Keywords： transimissity     HITEMP     HITRAN     Planck mean absorption coefficients    

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Pareto lexicographic α-robust approach and its application in robust multi objective assembly line balancing

Ullah SAIF,Zailin GUAN,Baoxi WANG,Jahanzeb MIRZA

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 3,   Pages 257-264 doi: 10.1007/s11465-014-0294-x

Abstract: application of the proposed method on a simple problem of multi objective optimization of simple assembly line

Keywords： Pareto     lexicographic α-robust     assembly line balancing    

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Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy

TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 49-53 doi: 10.1007/s11684-007-0010-x

Abstract: The aim of this paper is to construct a specific and high-performance gene therapy system for glioma.Our primary results showed that in U251 and BT325 cell lines, the activity of GFAP promoter was 16.40The glioma cells showed typical apoptotic signs 90 hours after the transient transfection of GFAP-BaxαIn these primary experiments, it showed that 6HRE-GFAPBaxα system could promote glioma cell apoptosisIt was specific and effective for glioma gene therapy.

Keywords： GFAP-Baxα     BT325     Fibrillary     apoptotic     specificity    

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Title Author Date Type Operation

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Journal Article

Experimental study on BPA uptake of glioma cell lines

Yang Lei,Wang Xiao,Sui Li,Kong Fuquan,Hao Xiaojuan,Zheng Jieying,Ma Nanru,Cui Suzhen,Liu Quanwei,Zhao Kui

Journal Article

Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Journal Article

Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cellline A549

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cellline via ERKs pathway

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Journal Article

Acoustic fault signal extraction via the line-defect phononic crystals

Journal Article

Calculations of narrow-band transimissities and the Planck mean absorption coefficients of real gases using line-by-line

Huaqiang CHU, Mingyan GU, Huaichun ZHOU, Fengshan LIU

Journal Article

Pareto lexicographic α-robust approach and its application in robust multi objective assembly line balancing

Ullah SAIF,Zailin GUAN,Baoxi WANG,Jahanzeb MIRZA

Journal Article

Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy

TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo

Journal Article